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The best-known red blood cell intrinsic mechanism of adaptation is an increase in bisphosphoglycerate (2,3-DPG) that shifts the Hb-O 2 dissociation curve to the right: this can be expected if the flow of glycolysis is impaired downstream, but not upstream, of the Rapoport-Luebering cycle (Figure 1)

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Bukasa, Tine Jess, Mohammed Nabil Quraishi Received January 25, 2026 Accepted April 12, 2026 Published online June 1, 2026 DOI: [Epub ahead of print] Abstract PDFSupplementary MaterialPubReaderePub Background/Aims To determine time to diagnosis (TTD) and its impact on surgery and advanced therapy (AT) burden in inflammatory bowel disease (IBD) in a multi-ethnic United Arab Emirates (UAE) cohort, a region in the acceleration phase of IBD incidence