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However, these peptides address fundamentally different conditions -- oveporexton targets narcolepsy-related wakefulness deficits while DSIP aims to promote deeper sleep in insomnia
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Optimization of ABT-737 yielded the oral analog ABT-263 ( navitoclax ), which retained a similar binding profile to BCL-2/BCL-XL but had limited clinical utility due to dose-limiting thrombocytopenia caused by BCL-XL inhibition in megakaryocytes and platelets [128,130]
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