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The negative feedback loop of the HPA axis. CRH =... | Download Scientific Diagram
[Note: This reaction is analogous to the formation of cyclic AMP by adenylate cyclase, except that this guanylate cyclase is not membrane associated.] The resultant rise in cGMP causes activation of protein kinase G, which phosphorylates Ca 2+ channels, causing decreased entry of Ca 2+ into smooth muscle cells
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