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Introduction Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder characterized by deficits in social communication with restricted and repetitive behaviors (Lord et al., 2019), and Cre-loxp systems (Mclellan et al., Progress in Gene Editing Techniques Gene editing is a genetic engineering technology that can modify, delete, or insert a small piece of DNA at a specific point in the genome of cells and organisms, which holds great promises in the fields of gene detection, gene function regulation, drug research and disease treatment (Cao et al., 2018)

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