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Clinical evidence on the involvement of gut-related factors in osteoporosis led us to undertake the core concept of the gut–bone axis and systematically summarize that the intestinal intrinsic structure, gut microbiota, and derived metabolites, with the immune and endocrine routes as the intermediate transitions, attain a bidirectional interplay with skeletal tissue through the gut–bone axis
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doi: 10.1016/j.nut.2007.05.004
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