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Table 5 summarizes several potential synthetic compounds and natural products that have clinically proven to inhibit the HIF-1α activity at the transcriptional and translational level in TNBC, such as inhibiting the mRNA level of HIF-1α and their dimerization with HIF-1β as well as accelerating the degradation of the HIF-1α protein
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Plasma levels of estradiol and sex hormone-binding globulin were estimated with double anti-body radioimmunoassays (Bioreference Lab, New York, NY)
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