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In white adipose tissue of obese, insulin-resistant and aged mammals, NNMT is dramatically upregulated — and because it consumes both the universal methyl donor (SAM) and the NAD⁺ precursor (nicotinamide), its hyperactivity simultaneously depletes the cellular methylation reserve and the NAD-salvage pool [1,2]
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Size:10mg (10-Pack)
The Mayo Clinic notes that even at therapeutic mega-doses, side effects are uncommon and mild: headache, nausea, diarrhea, fatigue, and a tingling sensation in extremities
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