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An NNMT inhibitor like 5-amino-1MQ could help by stimulating the synthesis of NAD+, a vital cofactor in the electron transport chain
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Crujeiras, Pissios, Moreno-Navarrete, and colleagues, writing in Molecular Nutrition and Food Research in 2018, identified an epigenetic signature in human adipose tissue linked to NNMT gene expression, reinforcing the idea that the methylation axis is a live variable in human fat biology rather than a rodent-only phenomenon
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