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APAP is an over-the-counter medicine, which has been recommended by referent organisations such as the WHO, the Food and Drug Administration, the American Geriatrics Society ( Reference Fine 75 , Reference Ferrell, Argoff and Epplin 78 ) , the OsteoArthritis Research Society International ( Reference Zhang, Moskowitz and Nuki 85 ) , the European League Against Rheumatism ( Reference Jordan, Arden and Doherty 86 , Reference Zhang, Doherty and Arden 87 ) and the National Institute for Health and Clinical Excellence ( 88 ) to treat pain of small to moderate intensity
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