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Introduction Astaxanthin, known as 3,3′- dihydroxy- β, β’- carotene-4,4′- dione, is a keto carotenoid known for its remarkable antioxidant, anticancer, and immune-boosting properties and widely applied in the food, aquaculture, cosmetics, and healthcare industries ( Phaffia rhodozyma (also known as Xanthophyllomyces dendrorhous ) is an ideal source of astaxanthin and has served as the prime candidate for astaxanthin production by microbial fermentation