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In addition, a complete lack of prevailing Sm-p80–specific immunoglobulin E in high-risk or infected populations was observed, thus minimizing the risk of hypersensitivity reaction following vaccination with Sm-p80 in humans ( In order to dissect the role(s) of antibodies in Sm-p80 mediated protection, pooled sera from mice immunized with Sm-p80-DNA or purified IgG from baboons immunized with Sm-p80-DNA were transferred intravenously into naïve mice, respectively, prior to challenge with cercariae
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NAM treatment significantly reduced ROS accumulation in the cytosol (Fig
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