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A widely integrated gene expression profile (GEP) assay is AlloMap, which has been made available as a monitoring tool for heart transplant recipients since 2005 ( p =0.03)

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54 SIRT3, owing to its unique hydrophobic pocket structure that accommodates the hydrocarbon moiety of lysine lactate, exhibits distinct binding mechanisms compared to other deacetylases and demonstrates more efficient deacetylation activity for water-soluble hydroxyl modifications (Table 1)