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What they found: Mean weight loss: −2.6 kg vs −2.3 kg placebo , a difference of only 0.3 kg (≈1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug
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It is thought that substrate reduction is a prerequisite for degradation, and ERAD substrates have long been known to associate with thiol isomerases including ERp90, ERp57, and PDI (Gillece et al., 1999
Columns can be used as a spin format of gravity flow columns
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