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As a GHRH analog, sermorelin may share these sleep-promoting properties Physiological GH release — sermorelin stimulates GH in a pulsatile pattern that mimics natural physiology, including the nocturnal sleep-onset pulse Clinical precedent — sermorelin was previously FDA-approved for GH-deficient children, providing a longer clinical safety track record than most research peptides Age-related application — sermorelin has been studied specifically in older adults, where the decline in both GH secretion and sleep quality occurs simultaneously Important Considerations# The direct sleep-promoting effects of GHRH are better documented than those of sermorelin specifically