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These mechanisms could potentially explain Aβ aggregation but they require further investigation, although difficult due to the high sensitivity of Aβ aggregation to experimental conditions such as pH and oxygenation, and the influence of other factors in vivo such as Aβ binding to lipids and cell surface gangliosides (Morgado and Garvey, 2015), ApoE (Xia et al., 2024), and potentially bacterial amyloids (Elkins et al., 2024)