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Some biological roles of melatonin in plants are similar to those in animals, such as regulation of circadian rhythms 12,36,37,38,39,40 , scavenging of reactive nitrogen species (RNS) and reactive oxygen species (ROS) 13,42,43,44,45,46 and regulation of innate immunity 22,32,33,41,47,48

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The generalizability of findings is also often limited by insufficient consideration of individual differences, such as genetic background, baseline nutritional status, gut microbiota composition, and specific OA phenotypes (e.g., metabolic vs