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In this regard, the intranasal route is a promising delivery method to obtain greater efficacy in maintaining optimal drug concentrations in the brain compared to parenteral injections [17-20]
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These numbers explain why tirzepatide has generated extraordinary demand and why the dosing protocols follow such a careful titration schedule: you start at 2.5 mg weekly for four weeks, increase to 5 mg, then continue stepping up through 7.5 mg, 10 mg, 12.5 mg, and potentially 15 mg depending on clinical response and tolerability
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