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Recent studies have also shown that disruption of mitochondrial membrane integrity leads to the release of mitochondrial molecules, such as mtDNA, which activates inflammatory signaling in macrophages 13 , 16
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Anatomical and functional changes at the BBB with hyperlipidemia A commonly used animal model for studying hyperlipidemia is the apolipoprotein E-deficient (ApoE −/− ) mouse
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