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Preclinical studies in animals have shown that opioid peptides do not induce central side effects [255,256,257], positioning them as a potentially effective and safe alternative to conventional analgesics—many of which (e.g., diclofenac) impair wound healing or have a limited systemic penetration but still carry a risk of central nervous system (CNS) side effects (as is the case with regular opioids)
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