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[DOI] [PubMed] [Google Scholar] 122.Rafati Rahimzadeh M, Rafati Rahimzadeh M, Kazemi S, et al

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HQD inhibited the activity of the NF-κB signaling pathway by inhibiting the Ras-PI3K-Akt-HIF-1α signaling pathway, which in turn inhibited the M1 macrophage phenotypic markers iNOS and CXCL10 and the pro-inflammatory cytokines IL-1β and IL-6, while up-regulating the M2 macrophage phenotypic markers MR2 and Trem2 with the anti-inflammatory cytokines IL-4 and IL- 10, significantly reduced inflammation in the colon