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All of caregivers were family members, with most of caregivers were children of the patients (69.2%), and the rest of them are their spouse

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Keywords: IPF—idiopathic pulmonary fibrosis, fibrosis, oxidative stress, ROS—reactive oxygen species, antioxidant therapy 1 Introduction 1.1 Idiopathic Pulmonary Fibrosis Among all the idiopathic interstitial pneumonias, the most common form is idiopathic pulmonary fibrosis (IPF), whose incidence is estimated to be ranged between 2.8 and 9.3 per 100,000 people per year in North America and Europe (Barratt et al., 2018)