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Venous stasis ulcers, 1992 Trial: Bishop et al., Journal of Vascular Surgery (PMID 1495150) Design: prospective randomized, evaluator-blinded, three arms Participants: 86 evaluable patients Form tested: topical tripeptide copper complex, 0.4% cream Endpoint type: clinical, ulcer size reduction Outcome: the copper complex was no better than inert vehicle placebo Limitation: a genuine negative result in a reasonably sized human trial, rarely cited on vendor pages CO2 laser-resurfaced skin, 2006 Trial: Miller et al., Archives of Facial Plastic Surgery (PMID 16847171) Design: randomized, blinded evaluators, post-procedure regimen with or without GHK-Cu Participants: 13 patients completed Form tested: topical GHK-Cu skin care products Endpoint type: both objective and patient-reported Outcome: no significant difference in erythema, wrinkles, or objectively rated skin quality Outcome, secondary: patient-reported overall skin quality favored GHK-Cu at P = .04 Limitation: 13 completers cannot rule out a modest real effect, and an unblinded questionnaire is the study's weakest endpoint Male pattern hair loss, 2016 Trial: Lee et al., Annals of Dermatology (PMID 27489425) Design: placebo-controlled, three arms, six months Participants: 45 patients Form tested: a complex of 5-aminolevulinic acid and GHK, the peptide without copper Endpoint type: clinical, hair count, length, and thickness Outcome: hair count rose in both active arms over six months Limitation: the lower-dose arm beat the higher-dose arm, and length and thickness did not differ Limitation, form: this does not test GHK-Cu, and it cannot separate GHK from the 5-ALA beside it Scalp injections in a growth-factor blend, 2018 Trial: Kapoor and Shome, Journal of Cosmetic and Laser Therapy (PMID 29482481) Design: open-label, single-arm, no control group Participants: 1,000 patients Form tested: an injectable blend of VEGF, bFGF, IGF, KGF, thymosin beta-4, and copper tripeptide-1 Endpoint type: clinical, hair pull test and videomicroscopy Outcome: reduced hair fall in 83% of patients, with higher total hair count at one year Limitation: six active ingredients and no control arm, so nothing is attributable to copper tripeptide-1 Multi-ingredient topical products, 2024 and 2025 Trials: two open-label single-center studies of products containing copper tripeptide-1 (PMIDs 39449909, 41001334) Design: open-label, interventional, no placebo arm Endpoint type: instrument-measured scalp and skin parameters Outcome: statistically significant improvements in flaking, hydration, and scar appearance Limitation: multi-ingredient formulations with no control group, leaving the peptide's contribution unmeasured On hair loss specifically, the honest summary is narrow
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