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Furthermore, alterations in sulfur metabolism have been reported in AD and PD ( 3 Microbiome-based interventions The numerous interactions between the microbiota, the gut, and the brain, and findings highlighting how these interactions are disrupted in NDDs motivate the development and optimization of interventions to modulate them

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36 PLA2 is expressed in OC effusion, 37 and studies have shown that targeting lipogenesis with the metabolic inhibitor PFK158 attenuates the expression of PLA2 subtypes in an autophagy-dependent manner, which can offset the progression of OC and suggests that great potential exists for using targeted phospholipases in the treatment of OC