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These experiments helped justify human development, but they have important limits: rodent energy balance and dosing conditions do not replicate long-term human obesity

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Adults with a BMI of 30 kg/m² or higher-or at least 27 kg/m² with weight-related comorbidities-who have not succeeded with lifestyle changes alone and who do not have contraindications such as heart disease, uncontrolled hypertension, glaucoma, hyperthyroidism, pregnancy, or a history of drug abuse