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The loss of MT3 triggers the activation of the NRF2 pathway, leading to the inhibition of RANKL-induced ROS production In osteoclastogenesis, RANKL-induced activation of MAPKs (ERK, JNK, and p38), NF-κ-B, and the PI3K/AKT pathways depends on ROS generated by RANKL and MT has a protective role against oxidative stress [34,35,36,37]