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In contrast-induced acute kidney injury (CI-AKI), the PINK1/Parkin pathway also protects RTECs from apoptosis by reducing oxidative stress and inhibiting nucleotide-binding oligomerization domain-like pyrin domain containing protein 3 (NLRP3) inflammasome production[114]
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Genetic reduction of NNMT and chemical inhibition by a small molecule are different experimental interventions, so findings cannot be transferred between them without direct support
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