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Mechanistic studies indicate that exercise-induced muscle contraction promotes the release of myokines (e.g., IL-6), which inhibit nuclear translocation of NF-κB in hepatic Kupffer cells (Figure 2) (Milkovic et al., 2023)

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Elevated levels of Hcy (hyperhomocysteinemia) in the body are associated with increased risk for diseases such as cardiovascular diseases, Alzheimer’s disease [44, 45]