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What they found: 4,192 human genes change expression by ≥ 2× in response to GHK-Cu (31.2 % of the human genome) Of these 2,296 genes up-regulated , 1,896 down-regulated Pattern of changes: a “rejuvenating” signature, genes typically associated with ageing are down-regulated, regenerative genes up-regulated DNA repair , strong up-regulation of genes in BER, HR, NER pathways Mitochondrial biogenesis , increase in the number of mitochondria in cells Anti-apoptotic signal , protection against cell death Down-regulation of cancer signals , some oncogenes decreased Why it matters: This is the strongest evidence for the pleiotropic nature of GHK-Cu

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For peptide tools, it is also common to document the number of handling events, the dilution series logic, and any intermediate stock strategies so later replications can be performed under the same assumptions