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[2] Neurological manifestations include subacute combined degeneration of the spinal cord and peripheral neuropathy (in the form of glove and stocking paraesthesia and trichodynia)

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Size:Discovery Size (10 mL)

In this study, a significant decrease in cell viability after XPF knockdown, which also reduces ERCC1 levels, was observed in the most resistant tumor cell line, confirming that DNA repair has a fundamental role in cisplatin resistance and variation in the protein levels of XPF and ERCC1 can explain, at least partially, the acquired resistance in tumors when compared to a normal fibroblast