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Sustained VEGF delivery over ~1 month was achieved, with the PLG–VEGF scaffold significantly increasing reperfusion of, and capillary density within, ischemic murine hindlimb as compared to empty scaffolds (Sun et al., 2005)
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However, the skin demonstrates the ability to restore normal CAT activity within a period of 4 weeks after exposure, a period influenced by the patient’s age (39, 40)
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