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Several enzymes involved in ATP production contain Fe-S clusters in the active site and are subject to similar inactivation by superoxide, including oxoglutarate dehydrogenase of the tricarboxylic acid cycle, as well as ETC complexes I–III
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Specific signaling pathways, including RhoA and phosphatidylinositide 3-kinases (PI3Ks), mediate these processes, and their specific inhibitors abolish ROS-induced monocyte migration across the BBB (Poulet et al., 2006
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