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These aged cells harm your skin in two ways: They stop working - Senescent fibroblasts no longer make collagen and elastin, which leaves skin unable to repair damage effectively [19] They cause inflammation - These cells develop a "senescence associated secretory phenotype" (SASP) that triggers inflammation and breaks down skin structure [20] Low NAD+ speeds up senescence by reducing SIRT1 activity, which lowers p63 expression and cell growth [19]
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doi: 10.1097/00002826-200405000-00007
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