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Acne has many causes, including: Build-up of bacteria Overproduction of sebum, which clogs pores Hormonal imbalances Gut imbalances Genetics Smoking Stress Dietary triggers like dairy, sugar, and highly processed foods Comedogenic skin care products Skin barrier damage Also associated with the development of acne is oxidative stress, which doesn’t occur only after breakouts rear their head

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Since glutamate is one of the brain’s major excitatory neurotransmitters, this pathway has drawn interest in conditions such as obsessive-compulsive disorder (OCD), depression, bipolar disorder, and substance use disorders.11 29 The evidence is still uneven