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Recent 2.8 Å cryo-electron microscopy (cryo-EM) reconstructions reveal that agonist engagement drives an outward swing of transmembrane helix 6 and creates an open intracellular cavity that pre-associates with G s , clarifying how the receptor achieves rapid activation and sustained cyclic adenosine monophosphate (cAMP) output [10]
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However, at this time it is not possible to say what the prevalence figure is for each of HSD and hEDS separately because this has not been studied yet
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