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We focused on the m 6 A RNA demethylase FTO given its high lysosomal degradation rate, the emerging roles of both FTO and m 6 A RNA methylation in immune regulation 55,56,57 , including metabolic and transcriptional control in Tregs, and the potential broad impact of FTO-mediated changes in m 6 A RNA methylation 58 , a common RNA modification that influences mRNA stability and expression
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