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The development of derivatives such as hydroxytyrosyl oleate (HTX-OL) encapsulated in lipid nanoparticles has shown improved cellular uptake, molecular stabilization and controlled release [93,94]
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The results showed that NaT treatment caused the downregulation of SIRT1 as well as its direct downstream target PGC1- α in acinar cells, and both were increased by VB 12 in a concentration-dependent manner (Figures 3(f)–3(h))
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