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At the infection site, the low intracellular calcium concentration triggers the release mechanism of the nanocrystals, allowing the drug to be directly released inside the cells, thereby avoiding systemic tissue damage caused by Amphotericin B ( 5.6 Antifungal compounds of traditional Chinese medicine will become a new star Approximately 80% of antibiotics currently used in clinical practice are derived from natural products, underscoring the value of natural sources in drug discovery (Newman et al., 2003)

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Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans