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The GHK tripeptide binds Cu²⁺ in a planar tetradentate (4N) configuration involving: (1) the N-terminal α-amine nitrogen of Gly¹, (2) the deprotonated amide nitrogen of the Gly¹-His² peptide bond, (3) the N(π) imidazole nitrogen of His², and (4) the amide nitrogen of the His²-Lys³ peptide bond
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