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Lipid overload, defective fatty acid handling and mitochondrial dysfunction accelerate terminal exhaustion, whereas signalling of checkpoint receptors such as PD-1 and CTLA-4 further suppresses glycolytic and mitochondrial fitness 38,39,40
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Osteocalcin, secreted by osteoblasts, has been shown to be closely associated with cognition and emotional regulation, suggesting that bone-derived signals may profoundly influence neural health ( At the molecular level, several critical signaling pathways have been identified as mediators of neural regulation of bone cell function
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