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Dose titration strategies significantly reduce adverse event incidence: starting with 25% of target dose for the first week, increasing to 50% in week two, 75% in week three, and full dose by week four reduces overall side effect rates from 35% to 18% [30]

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248 Theoretical risks include health problems in offspring related to genetic and epigenetic effects of oxidative stress, which may occur as a result of the procedure or may be inherited via the infertile father